The use of biocapacitance as an on-line PAT
tool for continuously monitoring viral vector
vaccines production in cell culture processes

Live virus vaccine (LVV) processes are not well understood in terms of changes in the critical quality attributes and analytical assays that can track/correct these changes in manufacturing. The lack of tools to directly monitor and measure these processes results in longer iteration time for process development and process characterization. This leads to significantly longer times to launch LVV’s against infectious diseases in comparison to, say, mRNA vaccines.

Merck published a paper which introduces the use of biocapacitance as an on-line PAT tool for continuously monitoring viral vector vaccines production in cell culture processes.

The work was performed using two viral vector-based vaccine candidates. The viral vectors used were VSV and an attenuated Measles virus.

The ABER capacitance probe was used to track the entire process for production of these viral vectors at different scales – 3L, 50L and 2000L.

In this report you will learn about

Real-time monitoring
& control
Automatically
control complex
feed rates
Sensors for
conventional &
single use biorectors

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